Mexedrone is a cathinone-based research chemical which was completely legal in the EU, its chemical structure resembles that of currently unavailable mephedrone.
Despite the efforts to limit or completely outlaw experimentation with novel research chemicals, there are still numerous legal alternatives that could provide researchers with a chance to study and classify them. The recent bans have pushed many sought-after research materials underground, which poses a problem for scientists who want to operate within the confines of the law. In some cases, the solution is to purchase a closely-related chemical that has not been placed on the list of scheduled substances and use it as a substitute for the desired chemical agent. However, for some chemical agents it isn’t so simple to identify a suitable replacement that has similar enough chemistry to draw reasonable comparisons.
For example the previously neglected cathinone, known as 4MMC or mephedrone gained a lot of attention a few years ago due to the fact it is structurally similar to MDMA. It was however quickly banned in most European countries due to fears of abuse. In this way, research potentials have been severely limited, forcing chemists around the world to look for new formulas that have never been synthesised before. After more than two years of hard work, a veteran team of scientists announced that a new analogue of mephedrone has been created and that it will be available under the name mexedrone. The new chemical is just as stable and suitable to work with, but it comes with the additional security of being produced and delivered by reputable vendors rather than black market dealers. This novel substance is very similar to 4MMC, but it has slight molecular differences that could significantly alter the way the chemical behaves in interaction with other molecules.
Chemically speaking mexedrone belongs to the cathinone family along with Methylone, Mephedrone and MDPV. Cathinones feature a phenetylamine core with an alkyl group and a ketone group attached to the molecule. This means the substance can be expected to have high potential for synaptic interaction. Typically, chemicals from this group act as powerful modifiers of neurotransmitter re-uptake, mainly for monoamine neurotransmitters such as serotonin, dopamine and norepinephrine which give users that ‘feel good’ and focussed sensation. Exact values for each neurotransmitter vary from substance to substance, which explains why each substance has a distinct pharmacological profile – some are more likely to exhibit entactogenic features such as the ‘loved-up’ feeling MDMA produces, while others have more of a stimulant-type impact similar to that of amphetamines or cocaine.
Since Mexedrone is practically untested with little to no scientific papers covering this novel research chemical, the only way to determine its true characteristics would be to conduct systematic experiments in a controlled setting.
Still, some conclusions can be drawn from analogies with mephedrone. After all it is the compound which mexedrone was modelled on and the chemical differences are minor, as both are cathinone-based varieties on the same molecule. Despite strong affinity for interaction with the dopamine system in the brain, this chemical was found to have far lower neurotoxicity than related substances such as methamphetamine. It is also highly hydrophilic, which limits the rate of its absorption into cells and affects the optimal quantities needed to conduct laboratory testing relative to other substances. It should be noted that mephedrone was actively studied for just a few short years before it was placed under restrictions, and as a result very few peer reviewed scientific reports were ever commissioned. Many details about the pharmacology of the substance are unknown, especially when it comes to biochemical mechanisms the substance can trigger. That just implies how foggy is our present picture about mexedrone and how urgently the substance needs to be subjected to systematic scientific study with quantitative methodology.
The goal of the team was to create a product that would most closely resemble mephedrone in appearance as much as in chemistry, so the first form of the substance to be released were crystal shards. This format is convenient for transport and storage, but it doesn’t allow as precise measurement as the powder form, which motivated us to continue with research until the substance could be delivered in both formats. This was accomplished in September 2015, and white powder mexedrone has just been made available for purchase through our website. The manufacturing process is strictly controlled and conducted in state-of-the-art facilities, which allows us to monitor the quality of the final product and ensure that each shipment is reliable. Both forms of the substance are chemically identical and of equally high purity, so buyers can decide based on their own convenience.
It goes without saying that presence of a new phenetylamine-based chemical agent is opening up new possibilities for researchers worldwide, especially in Europe. This field of research was suffering from limited access to research materials and inability to conduct experiments legally, but the launch of the new product will change that. Researchers specializing in cathinones can take advantage of mexedrone’s launch to restart their studies and measure the physical and chemical properties of this substance under laboratory conditions. In addition to better theoretic understanding of this chemical group, advanced research could yield important findings in the fields of medicine, pharmacology and biochemistry, and even lead to development of new solutions for some of the current challenges. Mexedrone could also have some unique features that other cathinones don’t, which makes its quick adoption into research schedules a goal worth pursuing.
Research chemical suppliers were receiving large numbers of enquiries about mexedrone leading up to its launch and UK based vendor Rapid Chems (now defunct) reported very strong sales after their initial launch and sales remained above average until the UK’s NPS bill came into force.
Average 300mg orally
Mexedrone Trip Reports
300mg Mexedrone – Experienced user (Hosted on UKCR)
Trusted Mexedrone Suppliers
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[Updated 13/08 to include new information about Mexedrone and update supplier information]
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